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KMID : 1098420000080010021
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Korean Journal of Medicinal Crop Science
2000 Volume.8 No. 1 p.21 ~ p.28
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Comparison of biological activity according to extracting solvents of four Acanthopanax root bark
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김영길/Kim, Young Gil
한종수/이미경/이진하/이현용/김승경/Han, Jong Soo/Lee, Mi Kyoung/Lee, Jin Ha/Lee, Hyeon Yong/Kim, Sung Kyoung
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Abstract
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The biological activities of water, ethanol and 50% ethanol extracts from Acanthopanax root bark were compared. 94% of Hep3B cell growth was inhibited by adding 1.0g/L of 50% ethanol extracts from A. senticosus root bark. It was also showed that above 90% of A549 cell growth was inhibited by adding 1.0g/L of 50% ethanol extracts. The 50% ethanol extracts of A. sessiliflorum root bark showed that the extracts selectivity were from 1.5 to 3.4 by adding all samples. For screening immunomodulating activities, Jurkat(T-cell) was showed that the cell growth and viability were more increased and activited 275% by adding the 50% ethanol extracts from A. senticosus root bark. The result of anti-mutagenicity of 50% ethanol extracts of A. senticosus root bark was most effective than any other samples. The enhancement of glutathione-S-transferase activity was increased 241% by adding 1.0g/L 1 : 1 extracts of A. senticosus root bark. 72% of oxidation was inhibited by adding 1.0g/L of 50% ethanol extracts from A. senticosus root bark.
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KEYWORD
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Acanthopanax sp., extracts solvents, biological activity
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